The 2008 champion, seeded second, won 6-3 6-2 in one hour and 18 minutes at a cool and blustery Melbourne Park.
Tenth seed Makarova upset third seed Simona Halep 6-4 6-0 in Tuesday's opening match.
Rafael Nadal plays Tomas Berdych later, with Andy Murray facing Nick Kyrgios in the night session.
Jamie Murray's Australian Open came to an end with defeat in round two of the mixed doubles.
After a strong start, Murray and Taiwain's Hao-Ching Chang lost 3-6 6-4 10-5 to fourth seeds Alexander Peya and Andrea Hlavackova on court two.
"Fly high. Sing your own song." Maria Sharapova scrawls a message for the world on the camera after her win over Eugenie Bouchard.
"That's a tough question. I just want to leave it." Ekaterina Makarova is asked whether Florida-resident Maria Sharapova feels "different" to the other Russian players.
"I cannot say pressure. Just I was a little bit stressed." Simona Halep is at a loss to explain why her 'A' game deserted here.











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